Differential Effects of Gangliosides on Ig Production and Proliferation
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چکیده
The effects of gangliosides on human B-cell responses were studied. Of various gangliosides tested, only GM2 and GM3 inhibited production of lgG subclasses and IgM, but not IgA subclasses, and thymidine uptake by human B cells stimulated with SAC plus interleukin-2 (IL-2). In contrast, GM1, GDla, GDlb, GD3, GTlb, and GQlb were without effects. GM2and GM3-induced inhibition were specific, because each was blocked by a corresponding antibody. Of various cytokines tested, tumor necrosis factor-cr {TNF-a) alone counteracted GM2and GM3-induced inhibitions of Ig production and thymidine uptake, whereas other cytokines including IL-lp, IL-3, IL-5, IL-6, and interferon-y each failed to
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تاریخ انتشار 2002